Open AccessEvaluation of Human Immunodeficiency Virus Biomarkers
Author(s) -
Bryan Lau,
Stephen J. Gange,
Gregory D. Kirk,
Richard D. Moore
Publication year - 2009
Publication title -
epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.901
H-Index - 173
eISSN - 1531-5487
pISSN - 1044-3983
DOI - 10.1097/ede.0b013e3181a71519
Subject(s) - interquartile range , medicine , cohort , marginal structural model , concordance , confidence interval , cohort study , credible interval , antiretroviral therapy , proportional hazards model , viral load , human immunodeficiency virus (hiv) , immunology
Among individuals infected with the human immunodeficiency virus (HIV), biomarkers that predict mortality are also used to determine the time when antiretroviral therapy is initiated. No studies have evaluated the impact of the frequency of marker measurements for either their predictive value of mortality or how they may influence inference of the effect of therapy initiation in analyses from observational data.