Open AccessElevated Risk of Nicotine Dependence Among Sib-pairs Discordant for Maternal Smoking During Pregnancy
Author(s) -
Edmond D. Shenassa,
George D. Papandonatos,
Michelle L. Rogers,
Stephen L. Buka
Publication year - 2015
Publication title -
epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.901
H-Index - 173
eISSN - 1531-5487
pISSN - 1044-3983
DOI - 10.1097/ede.0000000000000270
Subject(s) - pregnancy , nicotine , medicine , obstetrics , nicotine dependence , biology , genetics
Compelling evidence links maternal smoking during pregnancy with elevated risk of nicotine dependence among the offspring. However, no study to date has examined the maternal smoking during pregnancy-nicotine dependence link among sibling-pairs discordant for maternal smoking during pregnancy. We tested two hypotheses that, if supported, suggest that the maternal smoking during pregnancy-nicotine dependence link may be physiologically mediated.