Open AccessOptimal CD4 Count for Initiating HIV Treatment
Author(s) -
Fiona M. Ewings,
Deborah Ford,
A. Sarah Walker,
James Carpenter,
Andrew Copas
Publication year - 2014
Publication title -
epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.901
H-Index - 173
eISSN - 1531-5487
pISSN - 1044-3983
DOI - 10.1097/ede.0000000000000043
Subject(s) - regimen , observational study , human immunodeficiency virus (hiv) , medicine , natural history , marginal structural model , immunology
In HIV infection, dynamic marginal structural models have estimated the optimal CD4 for treatment initiation to minimize AIDS/death. The impact of CD4 observation frequency and grace periods (permitted delay to initiation) on the optimal regimen has not been investigated nor has the performance of dynamic marginal structural models in moderately sized data sets-two issues that are relevant to many applications.