Open AccessAmbient Particulate Air Pollution and MicroRNAs in Elderly Men
Author(s) -
Serena Fossati,
Andrea Baccarelli,
Antonella Zanobetti,
Mirjam Hoxha,
Pantel Vokonas,
Robert O. Wright,
Joel Schwartz
Publication year - 2014
Publication title -
epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.901
H-Index - 173
eISSN - 1531-5487
pISSN - 1044-3983
DOI - 10.1097/ede.0000000000000026
Subject(s) - single nucleotide polymorphism , confounding , microrna , particulates , in silico , snp , pollutant , gene , inflammation , biology , genetics , medicine , immunology , ecology , genotype
Ambient particulate matter (PM) has been associated with mortality and morbidity for cardiovascular disease. MicroRNAs control gene expression at a posttranscriptional level. Altered microRNA expression has been reported in processes related to cardiovascular disease and PM exposure, such as systemic inflammation, endothelial dysfunction, and atherosclerosis. Polymorphisms in microRNA-related genes could influence response to PM.