Open AccessHIV life cycle, innate immunity and autophagy in the central nervous system
Author(s) -
Kelly A. Meulendyke,
Joshua Croteau,
M. Christine Zink
Publication year - 2014
Publication title -
current opinion in hiv and aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.901
H-Index - 64
eISSN - 1746-6318
pISSN - 1746-630X
DOI - 10.1097/coh.0000000000000106
Subject(s) - context (archaeology) , innate immune system , autophagy , neuroscience , biology , disease , population , central nervous system , immunology , viral replication , immune system , virus , medicine , genetics , paleontology , apoptosis , environmental health , pathology
In this era of modern combination antiretroviral therapy (cART) HIV-associated neurocognitive disorders (HAND) continue to affect a large portion of the infected population. In this review, we highlight recent discoveries that help to define the interplay between HIV life cycle, the innate immune system and cellular autophagy in the context of the central nervous system (CNS).