Open AccessPosttranscriptional methylation of transfer and ribosomal RNA in stress response pathways, cell differentiation, and cancer
Author(s) -
Martyna Popis,
Sandra Blanco,
Michaela Frye
Publication year - 2016
Publication title -
current opinion in oncology/current opinion in oncology, with cancerlit
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 95
eISSN - 1080-8140
pISSN - 1040-8746
DOI - 10.1097/cco.0000000000000252
Subject(s) - biology , methylation , rna methylation , epigenetics , cellular differentiation , rna , dna methylation , methyltransferase , cell fate determination , transfer rna , regulation of gene expression , genetics , microbiology and biotechnology , gene expression , gene , transcription factor
Significant advances have been made in understanding the functional roles of evolutionarily conserved chemical modifications in RNA. By focusing on cytosine-5 methylation, we will highlight the latest insight into the mechanisms how posttranscriptional methylation contributes to cell fate decisions, with implications for cancer development.