Open AccessModulation of Macrophage Activity During Fracture Repair Has Differential Effects in Young Adult and Elderly Mice
Author(s) -
Jesse Slade Shantz,
Yan-yiu Yu,
Wells Andres,
Theodore Miclau,
Ralph Marcucio
Publication year - 2014
Publication title -
journal of orthopaedic trauma
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.221
H-Index - 121
eISSN - 1531-2291
pISSN - 0890-5339
DOI - 10.1097/bot.0000000000000062
Subject(s) - medicine , macrophage , differential effects , fracture (geology) , modulation (music) , differential (mechanical device) , composite material , genetics , in vitro , biology , philosophy , materials science , engineering , aerospace engineering , aesthetics
Advanced age is a factor associated with altered fracture healing. Delays in healing may increase the incidence of complications in the elderly, who are less able to tolerate long periods of immobilization and activity restrictions. This study sought to determine whether fracture repair could be enhanced in elderly animals by: (1) inhibiting macrophage activation, (2) blocking the M-CSF receptor c-fms, and (3) inhibiting monocyte trafficking using CC chemokine receptor-2 (CCR2) knockout mice.