Open AccessThe effect of specialist neurosciences care on outcome in adult severe head injury: a cohort study.
Author(s) -
Gordon Fuller,
Omar Bouamra,
Maralyn Woodford,
Tom Jenks,
Hemal H. Patel,
Timothy J Coats,
Peter Oakley,
Mendelow Ad,
Tim Pigott,
PJ Hutchinson,
Fiona Lecky
Publication year - 2011
Publication title -
pubmed
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 63
eISSN - 1537-1921
DOI - 10.1097/ana.0b013e3182161816
Subject(s) - medicine , odds ratio , confidence interval , confounding , glasgow coma scale , logistic regression , cohort , cohort study , head injury , odds , head trauma , intensive care unit , emergency medicine , surgery
Isoflurane exposure can protect the mammalian brain from subsequent insults such as ischemic stroke. However, this protective preconditioning effect is sexually dimorphic, with isoflurane preconditioning decreasing male while exacerbating female brain damage in a mouse model of cerebral ischemia. Emerging evidence suggests that innate cell sex is an important factor in cell death, with brain cells having sex-specific sensitivities to different insults. We used an in vitro model of isoflurane preconditioning and ischemia to test the hypothesis that isoflurane preconditioning protects male astrocytes while having no effect or even a deleterious effect in female astrocytes after subsequent oxygen and glucose deprivation (OGD).