Hypoxia-inducible Factor and Target Gene Expression Are Decreased in Patients with Sepsis | Zendy

Simon Schäfer | Zendy; Stilla Frede | Zendy; Sandra Winning | Zendy; Alexandra Bick | Zendy; Paktis Roshangar | Zendy; Joachim Fandrey | Zendy; Jürgen Peters | Zendy; Michael Adamzik | Zendy

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Hypoxia-inducible Factor and Target Gene Expression Are Decreased in Patients with Sepsis

Author(s) -

Simon Schäfer,

Stilla Frede,

Sandra Winning,

Alexandra Bick,

Paktis Roshangar,

Joachim Fandrey,

Jürgen Peters,

Michael Adamzik

Publication year - 2013

Publication title -

anesthesiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.874

H-Index - 234

eISSN - 1528-1175

pISSN - 0003-3022

DOI - 10.1097/aln.0b013e31828baa67

Subject(s) - lipopolysaccharide , adrenomedullin , sepsis , medicine , tumor necrosis factor alpha , messenger rna , hypoxia (environmental) , interleukin , cytokine , hypoxia inducible factors , gene expression , monocyte , microbiology and biotechnology , immunology , endocrinology , andrology , biology , gene , receptor , chemistry , biochemistry , organic chemistry , oxygen

Hypoxia-inducible factor-1 (HIF-1) is a molecular key player in response to hypoxemic/inflammatory conditions prevailing in sepsis. In a prospective observational study, we tested the hypotheses that sepsis affects HIF-1α messenger ribonucleic acid (mRNA) expression (primary hypothesis) and also (secondary hypotheses) the expression of the HIF-1α target genes adrenomedullin and β2-integrins. Furthermore, we tested that lipopolysaccharide administration increases HIF-1α mRNA and protein in naive and endotoxin-tolerant monocytes.

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