Open AccessARA290, a Peptide Derived from the Tertiary Structure of Erythropoietin, Produces Long-term Relief of Neuropathic Pain
Author(s) -
Maarten Swartjes,
Aurora M. Morariu,
Marieke Niesters,
Michael Brines,
Anthony Cerami,
Leon Aarts,
Albert Dahan
Publication year - 2011
Publication title -
anesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.874
H-Index - 234
eISSN - 1528-1175
pISSN - 0003-3022
DOI - 10.1097/aln.0b013e31822fcefd
Subject(s) - medicine , allodynia , neuropathic pain , erythropoietin , anesthesia , nerve injury , peripheral neuropathy , neuralgia , peripheral nerve injury , neuroprotection , pharmacology , receptor , nociception , hyperalgesia , endocrinology , sciatic nerve , diabetes mellitus
Exogenous erythropoietin inhibits development of allodynia in experimental painful neuropathy because of its antiinflammatory and neuroprotective properties at spinal, supraspinal, and possibly peripheral sites. The authors assess the effect of a nonhematopoietic erythropoietin analog, ARA290, on tactile and cold allodynia in a model of neuropathic pain (spared nerve injury) in rats and mice lacking the β-common receptor (βcR mice), a component of the receptor complex mediating tissue protection.
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