Open AccessInvolvement of Tuberomamillary Histaminergic Neurons in Isoflurane Anesthesia
Author(s) -
Tao Luo,
L. Stan Leung
Publication year - 2011
Publication title -
anesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.874
H-Index - 234
eISSN - 1528-1175
pISSN - 0003-3022
DOI - 10.1097/aln.0b013e3182207655
Subject(s) - histaminergic , medicine , anesthetic , saporin , isoflurane , anesthesia , propofol , pharmacology , righting reflex , histamine , reflex , immunotoxin , monoclonal antibody , antibody , immunology
The brain histaminergic system plays a critical role in maintenance of arousal. Previous studies suggest that histaminergic neurotransmission might be a potential mediator of general anesthetic actions. However, it is not clear whether histaminergic tuberomamillary nucleus (TMN) is necessarily involved in the sedative/hypnotic effects of general anesthetics.
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