Lymphocyte-based Determination of Susceptibility to Malignant Hyperthermia: A Pilot Study in Swine | Zendy

Saiid Bina | Zendy; John F. Capacchione | Zendy; Sheila M. Muldoon | Zendy; Munkhuu Bayarsaikhan | Zendy; Rolf Bünger | Zendy

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Lymphocyte-based Determination of Susceptibility to Malignant Hyperthermia: A Pilot Study in Swine

Author(s) -

Saiid Bina,

John F. Capacchione,

Sheila M. Muldoon,

Munkhuu Bayarsaikhan,

Rolf Bünger

Publication year - 2010

Publication title -

anesthesiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.874

H-Index - 234

eISSN - 1528-1175

pISSN - 0003-3022

DOI - 10.1097/aln.0b013e3181ee2cd0

Subject(s) - malignant hyperthermia , adenosine , medicine , adenosine deaminase , stimulation , lymphocyte , ryr1 , endocrinology , pathology , calcium , ryanodine receptor

Malignant hyperthermia susceptibility (MHS) is diagnosed by an invasive in vitro caffeine-halothane contracture test (CHCT) carried out on biopsied skeletal muscle tissue. We are presenting a novel blood test approach for malignant hyperthermia testing in a swine model. Our main aim was to determine whether adenosine production from lymphocytes after 4-chloro-m-cresol (4CmC) stimulation distinguishes homozygous swine carrying the Arg615Cys mutation in the ryanodine receptor type 1 (RyR1) gene (MHS swine) from normal swine.

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