Open AccessAcute Anemia Elicits Cognitive Dysfunction and Evidence of Cerebral Cellular Hypoxia in Older Rats with Systemic Hypertension
Author(s) -
Min Li,
Jessica A. Bertout,
Sarah J. Ratcliffe,
Maryellen F. Eckenhoff,
M. Celeste Simon,
Thomas F. Floyd
Publication year - 2010
Publication title -
anesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.874
H-Index - 234
eISSN - 1528-1175
pISSN - 0003-3022
DOI - 10.1097/aln.0b013e3181eaaef9
Subject(s) - medicine , hypoxia (environmental) , anemia , cerebral hypoxia , cognitive decline , cognition , disease , cardiology , physiology , ischemia , psychiatry , dementia , oxygen , chemistry , organic chemistry
Postoperative cognitive dysfunction occurs frequently after cardiac, major vascular, and major orthopedic surgery. Aging and hypertensive cerebrovascular disease are leading risk factors for this disorder. Acute anemia, common to major surgery, has been identified as a possible contributor to postoperative cognitive dysfunction. The effect of hypoxia upon cognition and the cellular and molecular processes involved in learning and memory has been well described. Cerebrovascular changes related to chronic hypertension may expose cells to increased hypoxia with anemia.
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