Effects of Intrathecal Ketamine in the Neonatal Rat | Zendy

Suellen M. Walker | Zendy; Björn Westin | Zendy; Ronald Deumens | Zendy; Marjorie R. Grafe | Zendy; Tony L. Yaksh | Zendy

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Effects of Intrathecal Ketamine in the Neonatal Rat

Author(s) -

Suellen M. Walker,

Björn Westin,

Ronald Deumens,

Marjorie R. Grafe,

Tony L. Yaksh

Publication year - 2010

Publication title -

anesthesiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.874

H-Index - 234

eISSN - 1528-1175

pISSN - 0003-3022

DOI - 10.1097/aln.0b013e3181dcd71c

Subject(s) - medicine , ketamine , spinal cord , anesthesia , lumbar spinal cord , nociception , central nervous system , lumbar , neuroprotection , hyperalgesia , pharmacology , endocrinology , surgery , receptor , psychiatry

Systemic ketamine can trigger apoptosis in the brain of rodents and primates during susceptible developmental periods. Clinically, spinally administered ketamine may improve the duration or quality of analgesia in children. Ketamine-induced spinal cord toxicity has been reported in adult animals but has not been systematically studied in early development.

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