Mechanisms of Impaired Glucose Tolerance and Insulin Secretion during Isoflurane Anesthesia | Zendy

Katsuya Tanaka | Zendy; Takashi Kawano | Zendy; T Tomino | Zendy; Hiroaki Kawano | Zendy; Tsuyoshi Okada | Zendy; Shuzo Oshita | Zendy; Akira Takahashi | Zendy; Yutaka Nakaya | Zendy

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Mechanisms of Impaired Glucose Tolerance and Insulin Secretion during Isoflurane Anesthesia

Author(s) -

Katsuya Tanaka,

Takashi Kawano,

T Tomino,

Hiroaki Kawano,

Tsuyoshi Okada,

Shuzo Oshita,

Akira Takahashi,

Yutaka Nakaya

Publication year - 2009

Publication title -

anesthesiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.874

H-Index - 234

eISSN - 1528-1175

pISSN - 0003-3022

DOI - 10.1097/aln.0b013e3181bbcb0d

Subject(s) - isoflurane , glibenclamide , medicine , endocrinology , insulin , potassium channel , pentobarbital , anesthetic , diabetes mellitus , anesthesia

Volatile anesthetics impair insulin secretion and glucose utilization; however, the precise mechanism of action that underlies these effects is unknown. The authors hypothesized that isoflurane inhibits glucose-induced inhibition of adenosine triphosphate-sensitive potassium channel activity in pancreatic beta cells, which could result in impaired insulin secretion and glucose tolerance.

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