Open AccessNew approaches to transcutaneous immunotherapy
Author(s) -
Richard Weiss,
Sandra Scheiblhofer,
Yoan Machado,
Josef Thalhamer
Publication year - 2013
Publication title -
current opinion in allergy and clinical immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.94
H-Index - 84
eISSN - 1528-4050
pISSN - 1473-6322
DOI - 10.1097/aci.0b013e328364f4df
Subject(s) - hypoallergenic , medicine , immunotherapy , immunology , immune system , allergen , immunization , sensitization , allergen immunotherapy , allergy
This review summarizes recent preclinical and human studies evaluating allergen-specific immunotherapy via the transcutaneous route, and provides a rationale for the application of modified allergens with reduced allergenicity. Furthermore, it covers approaches to generate hypoallergenic conjugates for specific dendritic cell targeting.