Open AccessThe role of lung epithelial ligands for Siglec-8 and Siglec-F in eosinophilic inflammation
Author(s) -
Takumi Kiwamoto,
Toshihiko Katoh,
Michael Tiemeyer,
Bruce S. Bochner
Publication year - 2013
Publication title -
current opinion in allergy and clinical immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.94
H-Index - 84
eISSN - 1528-4050
pISSN - 1473-6322
DOI - 10.1097/aci.0b013e32835b594a
Subject(s) - siglec , inflammation , medicine , eosinophilic , immunology , pathology , antibody
Siglec-8 and Siglec-F are single pass transmembrane inhibitory receptors found on the surface of human and mouse eosinophils, respectively, but very little is known about their physiologic glycan ligands. This article reviews the latest knowledge on this topic and outlines the strategies being used to further define the production and glycobiochemical nature of these molecules in the lung.