Open AccessBest Single Time Point Correlations With AUC for Cyclosporine and Tacrolimus in HIV-Infected Kidney and Liver Transplant Recipients
Author(s) -
Lynda Frassetto,
Clara Tan-Tam,
Burc Barin,
Matt Browne,
Alan R. Wolfe,
Peter Stock,
Michelle E. Roland,
Leslie Z. Benet
Publication year - 2014
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000441097.30094.31
Subject(s) - tacrolimus , medicine , dosing , pharmacokinetics , trough level , therapeutic drug monitoring , area under the curve , urology , transplantation , trough concentration , kidney transplantation , kidney , gastroenterology , ciclosporin , kidney transplant , pharmacology
Interactions between antiretrovirals (ARVs) and transplant immunosuppressant agents (IS) among HIV-infected transplant recipients may lead to lack of efficacy or toxicity. In transplant recipients not infected with HIV, tacrolimus (TAC) trough levels (C0) or cyclosporine (CsA) drawn at C0 or 2 hours after dosing (C2) correlate with drug exposure (area under the curve [AUC]/dose) and outcomes. Because of ARV-IS interactions in HIV-infected individuals, and the high rate of rejection in these subjects, this study investigated the correlations between IS concentrations and exposure to determine the best method to monitor immunosuppressant levels.