SYK, A NOVEL THERAPEUTIC TARGET FOR PTLD, DRIVES EPSTEIN BARR VIRUS (EBV)+ B CELL LYMPHOMA GROWTH AND SURVIVAL THROUGH ACTIVATION OF THE PI3K/AKT PATHWAY

Supplement to Transplantation July 27, 2008, Volume 86 Number 2S One patient was newly infected with HCV without actual consequences concerning liver function but received a well functioning graft of a 25 year old donor (s. patient and methods). Two patients with underlying HCV infection showed deterioriation of liver function one without correlation to transplantation one with genotype crossing. Of the 20 recipients without HCV infection transplanted with kidneys of anti HCV positive donors with negative HCV PCR none got infected. Mean waiting time of the study group was 12 months shorter than mean waiting time in the Eurotransplant region. Conclusion: Acceptance of kidneys of anti HCV positive donors increases the donor pool and is safe for recipients with chronic HCV infections. Also recipients without HCV infection can be transplanted safely if PCR is negative. In rare cases especially in old recipients HCV infection can be accepted as consequence of transplantation.