Open AccessIncreased Immunosuppression, Not Anticoagulation, Extends Cardiac Xenograft Survival
Author(s) -
Guerard W. Byrne,
William R. Davies,
Keiji Oi,
Vinay Rao,
Sumeet S. Teotia,
Davide Ricci,
Henry D. Tazelaar,
Randall C. Walker,
John S. Logan,
Christopher G.A. McGregor
Publication year - 2006
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000251387.40499.0f
Subject(s) - medicine , immunosuppression , sirolimus , tacrolimus , thrombosis , gastroenterology , transplantation , surgery , anticoagulant
Cardiac xenograft function is lost due to delayed xenograft rejection (DXR) characterized by microvascular thrombosis and myocardial necrosis. The cause of DXR is unknown but may result from thrombosis induced by antibody-mediated activation of endothelial cells and/or by incompatibilities in thromboregulatory interactions.