Open AccessEffects of Cyclosporin A on the Activation of Natural Killer T Cells Induced by ??-Galactosylceramide
Author(s) -
Takashi Kajiwara,
Yukihiro Tomita,
Shinji Okano,
Toshiro Iwai,
Y Yasunami,
Yasunobu Yoshikai,
Kikuo Nomoto,
Hirofumi Yasui,
Ryuji Tominaga
Publication year - 2007
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000250573.50046.89
Subject(s) - natural killer t cell , spleen , cytokine , immunology , transplantation , interferon gamma , flow cytometry , t cell , chemistry , endocrinology , immune system , biology , medicine
Natural killer T (NKT) cells play crucial roles in preventing autoimmune diseases and inducing transplantation tolerance. We investigated whether cyclosporin A (CsA), which is generally used in clinical transplantation and autoimmune disease therapy, could modulate the NKT cell activation induced by alpha-galactosylceramide (alpha-GalCer) treatment.