Open AccessTHYMECTOMY IMPAIRS BUT DOES NOT UNIFORMLY ABROGATE LONG-TERM ACCEPTANCE OF SEMI-IDENTICAL LIVER ALLOGRAFT IN INBRED MINIATURE SWINE TEMPORARILY TREATED WITH FK506
Author(s) -
Kenji Uryuhara,
Satoshi Ambiru,
JeanPaul Dehoux,
Fumitaka Oike,
Stéphanie Talpe,
Pierre Gianello
Publication year - 2004
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000121762.47432.15
Subject(s) - thymectomy , medicine , immunosuppression , miniature swine , mixed lymphocyte reaction , antibody , immune system , liver transplantation , transplantation , immunology , surgery , t cell , myasthenia gravis
Long-term acceptance of semi-identical orthotopic liver transplants (OLTs) in inbred swine is induced by a 12-day course of FK506. To study whether acceptance is attributable to central or peripheral immune mechanisms, the effect of complete thymectomy was determined.