Open AccessThe Calculated Genetic Barrier for Antiretroviral Drug Resistance Substitutions Is Largely Similar for Different HIV-1 Subtypes
Author(s) -
David A. van de Vijver,
Annemarie M. J. Wensing,
Gioacchino Angarano,
Birgitta Åsjö,
Claudia Balotta,
Enzo Boeri,
Ricardo Jorge Camacho,
MarieLaure Chaix,
Dominique Costagliola,
Andrea De Luca,
Inge Derdelinckx,
Zehava Grossman,
Osamah Hamouda,
Angelos Hatzakis,
R Hemmer,
Andy I. M. Hoepelman,
Andrzéj Horban,
Klaus Korn,
Claudia Kücherer,
Thomas Leitner,
Clive Loveday,
Eilidh MacRae,
I Maljkovic,
Carmen de Mendoza,
Laurence Meyer,
Claus Nielsen,
Eline Op de Coul,
Vidar Ormaasen,
Dimitrios Paraskevis,
Luc Perrin,
Elisabeth PuchhammerStöckl,
Lı́dia Ruiz,
Mika Salminen,
Jean-Claude Schmit,
François Schneider,
Rob Schuurman,
Vincent Soriano,
G Stanczak,
Maja Stanojević,
AnneMieke Vandamme,
Kristel Van Laethem,
Michela Violin,
Karin Wilbe,
Sabine Yerly,
Maurizio Zazzi,
Charles A. Boucher
Publication year - 2006
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/01.qai.0000209899.05126.e4
Subject(s) - drug resistance , protease , biology , virology , genetics , genetic variation , protease inhibitor (pharmacology) , drug , mutation , hiv 1 protease , lentivirus , human immunodeficiency virus (hiv) , gene , viral disease , enzyme , antiretroviral therapy , viral load , pharmacology , biochemistry
The genetic barrier, defined as the number of mutations required to overcome drug-selective pressure, is an important factor for the development of HIV drug resistance. Because of high variability between subtypes, particular HIV-1 subtypes could have different genetic barriers for drug resistance substitutions. This study compared the genetic barrier between subtypes using some 2000 HIV-1 sequences (>600 of non-B subtype) isolated from anti-retroviral-naive patients in Europe.