Open AccessHeme oxygenase-1 and acute kidney injury
Author(s) -
Karl A. Nath
Publication year - 2014
Publication title -
current opinion in nephrology and hypertension/current opinion in nephrology and hypertension, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.158
H-Index - 95
eISSN - 1080-8221
pISSN - 1062-4821
DOI - 10.1097/01.mnh.0000437613.88158.d3
Subject(s) - heme oxygenase , biliverdin , acute kidney injury , cytoprotection , heme , medicine , pharmacology , kidney , sepsis , oxygenase , chemistry , biochemistry , oxidative stress , enzyme
Heme oxygenase activity, possessed by an inducible heme oxygenase-1 (HO-1) and a constitutive isoform (HO-2), catalyzes the conversion of heme to biliverdin, liberates iron, and generates carbon monoxide. First shown in acute kidney injury (AKI), HO-1 is now recognized as a protectant against diverse insults in assorted tissues. This review summarizes recent contributions to the field of HO-1 and AKI.