Open AccessIntrarenal renin–angiotensin system in regulation of glomerular function
Author(s) -
L. Gabriel Navar
Publication year - 2014
Publication title -
current opinion in nephrology and hypertension/current opinion in nephrology and hypertension, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.158
H-Index - 95
eISSN - 1080-8221
pISSN - 1062-4821
DOI - 10.1097/01.mnh.0000436544.86508.f1
Subject(s) - tubuloglomerular feedback , renin–angiotensin system , angiotensin ii , endocrinology , medicine , renal function , paracrine signalling , angiotensin ii receptor type 1 , glomerular basement membrane , receptor , chemistry , kidney , macula densa , juxtaglomerular apparatus , glomerulonephritis , blood pressure
The purpose of this review is to provide an update on the current knowledge regarding the role of the intrarenal rennin-angiotensin system (RAS) in the regulation of glomerular function including glomerular dynamics and filtration rate, glomerular permeability and structural alterations during chronic increases in intrarenal angiotensin (Ang) II.