Open AccessNo Evidence of Vancomycin Minimal Inhibitory Concentration Creep or Heteroresistance Identified in Pediatric Staphylococcus aureus Blood Isolates
Author(s) -
Jennifer Goldman,
Christopher J. Harrison,
Angela Myers,
Mary Anne Jackson,
Rangaraj Selvarangan
Publication year - 2014
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/01.inf.0000436281.18687.0c
Subject(s) - etest , broth microdilution , minimum inhibitory concentration , staphylococcus aureus , microbiology and biotechnology , vancomycin , biology , medicine , antibiotics , bacteria , genetics
We evaluated vancomycin minimum inhibitory concentration (MIC) trends by 3 methods (broth microdilution, Etest and Vitek 2) in 208 Staphylococcus aureus blood isolates from 2006 to 2009 and assessed for heteroresistance. Vancomycin MICs did not increase nor was heteroresistance identified. Etest yielded higher MIC results than the other 2 methods. No MIC was >2 µg/mL by any testing method.