Open AccessRegulation of Catechol-O-Methyltransferase Expression in Human Myometrial Cells
Author(s) -
Melissa J. Wentz,
Mohammad Jamaluddin,
Robert E. Garfield,
Ayman AlHendy
Publication year - 2006
Publication title -
obstetrics and gynecology (new york. 1953. online)/obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.664
H-Index - 220
eISSN - 1873-233X
pISSN - 0029-7844
DOI - 10.1097/01.aog.0000243775.73788.11
Subject(s) - catechol o methyl transferase , estrogen , myometrium , lactacystin , methyltransferase , endocrinology , medicine , microbiology and biotechnology , chemistry , biology , biochemistry , methylation , proteasome inhibitor , apoptosis , uterus , allele , gene
The catechol-O-methyltransferase enzyme catalyzes the methylation of the catechol estrogens, 2- or 4-hydroxyestrogen, to 2- or 4-methoxyestrogen. Both the hydroxy estrogens and methoxy estrogens were shown to modulate the effects of estrogen. Because catechol-O-methyltransferase activity controls levels of these metabolites, it may help regulate the cellular estrogenic milieu. In this study, we examined the regulation of catechol-O-methyltransferase expression in human myometrial cells.