Open AccessDecay of K103N mutants in cellular DNA and plasma RNA after single-dose nevirapine to reduce mother-to-child HIV transmission
Author(s) -
Shayne Loubser,
Peter Balfe,
Gayle Sherman,
Scott M. Hammer,
Louise Kuhn,
Lynn Morris
Publication year - 2006
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/01.aids.0000222071.60620.1d
Subject(s) - nevirapine , reverse transcriptase , virology , lentivirus , population , biology , polymerase chain reaction , rna , transmission (telecommunications) , dna , mutation , virus , viral load , medicine , genetics , viral disease , gene , antiretroviral therapy , environmental health , electrical engineering , engineering
Single-dose nevirapine (sd-NVP) for prevention of mother-to-child HIV-1 transmission is associated with selection of resistant viral variants, particularly the Lysine (K) to Asparagine (N) mutation at codon 103 (K103N) of reverse transcriptase. As this may influence subsequent treatment responses, a better understanding of the dynamics of decay and persistence of this variant is needed.