Open AccessPanel of prototypical infectious molecular HIV-1 clones containing multiple nucleoside reverse transcriptase inhibitor resistance mutations
Author(s) -
Elizabeth Johnston,
Kathryn Dupnik,
Matthew J. Gonzales,
Mark A. Winters,
Soo-Yon Rhee,
Tomozumi Imamichi,
Robert W. Shafer
Publication year - 2005
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/01.aids.0000166098.54564.0c
Subject(s) - reverse transcriptase , nucleoside reverse transcriptase inhibitor , virology , reverse transcriptase inhibitor , drug resistance , human immunodeficiency virus (hiv) , biology , lentivirus , viral disease , sida , polymerase chain reaction , viral load , genetics , gene , antiretroviral therapy
We have created a panel of recombinant HIV-1 infectious clones containing common patterns of reverse transcriptase (RT) mutations responsible for resistance to each of the currently available nucleoside reverse transcriptase inhibitors (NRTI), and we have submitted the panel to the National Institutes of Health AIDS Research and Reference Reagent Programme. Testing the activity of new antiretroviral compounds against this panel of drug-resistant clones will determine their relative activity against many clinically relevant NRTI-resistant viruses.