Open AccessAPOPTOSIS AND ALLOGRAFT REJECTION IN THE ABSENCE OF CD8+ T CELLS1
Author(s) -
Yasuhiro Ogura,
Olivia M. Martinez,
Janeth C. Villanueva,
Jonathan F. Tait,
H. William Strausś,
Julian P T Higgins,
Kôichi Tanaka,
Carlos O. Esquivel,
Francis G. Blankenberg,
Sheri M. Krams
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200106270-00020
Subject(s) - granzyme b , cytotoxic t cell , cd8 , apoptosis , transplantation , granzyme , terminal deoxynucleotidyl transferase , fas ligand , allotransplantation , immunology , t cell , biology , programmed cell death , medicine , immune system , tunel assay , perforin , in vitro , biochemistry
The requirement for cytotoxic T lymphocytes during allograft rejection is controversial. We previously demonstrated that CD8+ T cells are not necessary for allograft rejection or for the induction of apoptosis in rat small intestinal transplantation. In this study, we examined the mechanisms of apoptosis and rejection after liver transplantation in the absence of CD8+ T cells.