Open AccessPREVENTION OF CHRONIC REJECTION IN MOUSE AORTIC ALLOGRAFTS BY COMBINED TREATMENT WITH CTLA4-Ig AND ANTI-CD40 LIGAND MONOCLONAL ANTIBODY1,2
Author(s) -
Hong Sun,
Владимир Субботин,
Christopher Chen,
Abdelouahab Aı̈touche,
Luis A. Valdivia,
M. H. Sayegh,
Peter S. Linsley,
John J. Fung,
Thomas E. Starzl,
Abdul S. Rao
Publication year - 1997
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199712270-00035
Subject(s) - cd40 , monoclonal antibody , medicine , transplantation , cd28 , antibody , immunology , blockade , allotransplantation , pathology , t cell , receptor , biology , immune system , in vitro , cytotoxic t cell , biochemistry
In this study, using a murine model of aortic allotransplantation, the role of blockade of signaling through CD28/B7 and CD40/CD40 ligand costimulatory pathways in the evolvement of posttransplant vasculopathy was examined.