Open AccessTargeted lymph-node immunization with whole inactivated simian immunodeficiency virus (SIV) or envelope and core subunit antigen vaccines does not reliably protect rhesus macaques from vaginal challenge with SIVmac251
Author(s) -
Xusheng Lü,
Hiroshi Kanazawa,
Liang Ding,
Shigetada Kawabata,
Judy Torten,
Seema Srinivasan,
Peter J. Dailey,
Jerry R. McGhee,
Thomas Lehner,
Christopher J. Miller
Publication year - 1998
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/00002030-199801000-00001
Subject(s) - simian immunodeficiency virus , virology , immunization , immunology , virus , antibody , lymph node , antigen , rhesus macaque , lentivirus , biology , medicine , viral disease
Sexual transmission of HIV is the most common route of HIV transmission throughout the world. To prevent sexually transmitted HIV infection, a vaccine is urgently needed. A previous report demonstrated the targeted immunization of the iliac lymph nodes with simian immunodeficiency virus (SIV) subunits protects rhesus macaques from rectal challenge with SIV. We sought to determine whether this immunization strategy could protect rhesus macaques from vaginal challenge with SIV.