Normal Mice Develop From Oocytes Injected With Spermatozoa with Grossly Misshapen Heads1 | Zendy

Victoria R. Burruel | Zendy; Ryuzo Yanagimachi | Zendy; W. K. Whitten | Zendy

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Normal Mice Develop From Oocytes Injected With Spermatozoa with Grossly Misshapen Heads1

Author(s) -

Victoria R. Burruel,

Ryuzo Yanagimachi,

W. K. Whitten

Publication year - 1996

Publication title -

biology of reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.366

H-Index - 180

eISSN - 1529-7268

pISSN - 0006-3363

DOI - 10.1095/biolreprod55.3.709

Subject(s) - biology , andrology , embryo , in vitro , organelle , embryogenesis , oocyte , embryonic stem cell , microbiology and biotechnology , genetics , gene , medicine

Because in the mouse some structurally abnormal spermatozoa can penetrate oocytes, we decided to determine whether mouse oocytes fertilized by spermatozoa with grossly misshapen heads are able to develop normally. We injected such spermatozoa from BALB/c mice individually into mature oocytes of hybrid mice B6D2F1. Eighty to ninety percent of the oocytes were activated and developed into blastocysts in vitro and, when transferred to foster mothers, some developed into apparently normal fertile adults. This finding indicates that a proportion of abnormal spermatozoa carry all the genome and organelles necessary for normal embryonic development and growth to fertile maturity.

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