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The observation that circulating thyroxine concentration increases during the breeding season of the ewe, coupled with the finding that thyroid hormones are required for the transition from the breeding season to anestrus in this species, led us to test the hypothesis that the transition to anestrus is driven by a rise in circulating thyroxine. Suffolk ewes were thyroidectomized (THX) late in the anestrous season. Thyroxine was then either not replaced or provided at doses that produced nadir, incremental (simulating the seasonal rise), or mildly hyperthyroid concentrations in serum. Additional ewes remained thyroid-intact. To monitor seasonal changes in reproductive neuroendocrine activity, the ewes were ovariectomized and received implants of constant-release Silastic capsules containing estradiol. Serum concentrations of LH and thyroxine were determined in samples collected twice weekly. In all groups, LH increased in mid-September, signifying that manipulation of thyroid status did not influence onset of the neuroendocrine breeding season. In thyroid-intact controls, LH decreased to low concentrations in mid-January, marking the neuroendocrine transition to anestrus. As expected, LH remained elevated through the end of the study (April) in THX controls not receiving thyroxine, confirming that the neuroendocrine transition to anestrus is dependent on thyroid hormones. The seasonal decrease in LH was seen in all ewes treated with thyroxine. This decrease in LH was neither advanced in mildly hyperthyroid ewes nor delayed in ewes exposed to low serum concentrations of thyroxine. These results lead to the conclusion that the seasonal increase in circulating thyroid hormone in the ewe does not drive the transition from the breeding season to anestrus.(ABSTRACT TRUNCATED AT 250 WORDS)

Thyroxine is Permissive to Seasonal Transitions in Reproductive Neuroendocrine Activity in the Ewe1