Estrogen-induced Increase in Eosinophil Number and Peroxidase Activity in Uterus of Genetically Mast Cell-deficient W/WV Mice1 | Zendy

Nobuyuki Terada | Zendy; Tetsumi Yamane | Zendy; Kunio Matsumoto | Zendy; Hidekazu Asai | Zendy; Yukihiko Kitamura | Zendy

Open Access

Estrogen-induced Increase in Eosinophil Number and Peroxidase Activity in Uterus of Genetically Mast Cell-deficient W/WV Mice1

Author(s) -

Nobuyuki Terada,

Tetsumi Yamane,

Kunio Matsumoto,

Hidekazu Asai,

Yukihiko Kitamura

Publication year - 1985

Publication title -

biology of reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.366

H-Index - 180

eISSN - 1529-7268

pISSN - 0006-3363

DOI - 10.1095/biolreprod33.4.899

Subject(s) - biology , eosinophil , eosinophilia , mast cell , estrogen , uterus , endocrinology , medicine , peroxidase , eosinophil peroxidase , immunology , andrology , enzyme , biochemistry , asthma

The role of mast cells in induction of uterine eosinophilia was investigated by using genetically mast cell-deficient (WB X C57BL/6)F1-W/Wv (hereafter called WBB6F1-W/Wv) mice. The injection of estradiol-17 beta (0.16 micrograms/g body weight) increased the peroxidase activity and eosinophil number in the uteri of castrated WBB6F1-W/Wv and WBB6F1-+/+ mice. Since no significant differences were detectable between these two type of mice, mast cells did not seem to be essential for the estrogen-induced uterine eosinophilia, at least in mice.

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