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Spraying estradiol-1713, progesterone or norethisterone intranasally in adult male rhesus monkeys (7.5-11 kg BW) at a daily dose of 30 pg/day for a period of 60 days resulted in a decrease of testicular size, arrest of spermatogenesis and a significant reduction in serum levels of testosterone. No changes were observed in the solvent-treated controls.

Effects of Intranasal Administration of Hormonal Steroids on Serum Testosterone and Spermatogenesis in Rhesus Monkey (Macaca mulatta)