Open AccessEffects of Intranasal Administration of Hormonal Steroids on Serum Testosterone and Spermatogenesis in Rhesus Monkey (Macaca mulatta)
Author(s) -
T. C. Anand Kumar,
A. Sehgal,
Gyula Dávid,
J.S. Bajaj,
M.R.N. Prasad
Publication year - 1980
Publication title -
biology of reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.366
H-Index - 180
eISSN - 1529-7268
pISSN - 0006-3363
DOI - 10.1095/biolreprod22.4.935
Subject(s) - nasal administration , testosterone (patch) , spermatogenesis , biology , endocrinology , medicine , hormone , norethisterone , physiology , pharmacology , population , environmental health , research methodology
Spraying estradiol-1713, progesterone or norethisterone intranasally in adult male rhesus monkeys (7.5-11 kg BW) at a daily dose of 30 pg/day for a period of 60 days resulted in a decrease of testicular size, arrest of spermatogenesis and a significant reduction in serum levels of testosterone. No changes were observed in the solvent-treated controls.
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