Open AccessRegulation of Luteinizing Hormone/Human Chorionic Gonadotropin Receptor Expression: A Perspective1
Author(s) -
K.M.J. Me,
Utpal M. Munshi,
Christine L. Clouser,
Anil K. Nair
Publication year - 2004
Publication title -
biology of reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.366
H-Index - 180
eISSN - 1529-7268
pISSN - 0006-3363
DOI - 10.1095/biolreprod.103.024471
Subject(s) - biology , receptor , luteinizing hormone , receptor expression , human chorionic gonadotropin , microbiology and biotechnology , progesterone receptor , estrogen related receptor gamma , enzyme linked receptor , gonadotropin , interleukin 21 receptor , gonadotropin releasing hormone receptor , follicle stimulating hormone receptor , hormone receptor , endocrinology , medicine , hormone , gonadotropin releasing hormone , follicle stimulating hormone , nuclear receptor , genetics , estrogen receptor , gene , transcription factor , cancer , breast cancer
The LH/hCG receptor, a member of the G protein coupled receptor family mediates the cellular actions of LH in the ovary. A considerable amount of information regarding its structure, mechanism of activation, and regulation of expression has emerged in recent years. Here we provide a brief overview of the current information on the structural organization of the receptor and the mechanism of receptor mediated signaling as well as an in-depth discussion on recent developments pertaining to the regulation of receptor expression. Specifically, we describe studies from our laboratory showing that the posttranscriptional regulation of the receptor involves an LH/hCG receptor mRNA-binding protein. We also propose a model to explain the loss of steady-state LH/hCG receptor mRNA levels during receptor down-regulation.
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