Multiresistance Genes of Rhizobium etli CFN42 | Zendy

Ramón González-Pasayo | Zendy; Esperanza MartínezRomero | Zendy

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Multiresistance Genes of Rhizobium etli CFN42

Author(s) -

Ramón González-Pasayo,

Esperanza MartínezRomero

Publication year - 2000

Publication title -

molecular plant-microbe interactions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.565

H-Index - 153

eISSN - 1943-7706

pISSN - 0894-0282

DOI - 10.1094/mpmi.2000.13.5.572

Subject(s) - phaseolus , efflux , biology , mutant , microbiology and biotechnology , gene , rhizobium , escherichia coli , kanamycin , transposable element , multiple drug resistance , salicylic acid , genetics , botany , antibiotics

Multidrug efflux pumps of bacteria are involved in the resistance to various antibiotics and toxic compounds. In Rhizobium etli, a mutualistic symbiont of Phaseolus vulgaris (bean), genes resembling multidrug efflux pump genes were identified and designated rmrA and rmrB. rmrA was obtained after the screening of transposon-generated fusions that are inducible by bean-root released flavonoids. The predicted gene products of rmrAB shared significant homology to membrane fusion and major facilitator proteins, respectively. Mutants of rmrA formed on average 40% less nodules in bean, while mutants of rmrA and rmrB had enhanced sensitivity to phytoalexins, flavonoids, and salicylic acid, compared with the wild-type strain. Multidrug resistance genes emrAB from Escherichia coli complemented an rmrA mutant from R. etli for resistance to high concentrations of naringenin.

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