Development of the Concept for Stem Cell-Based Developmental Neurotoxicity Evaluation | Zendy

Ellen Fritsche | Zendy; Marta Barenys | Zendy; Jördis Klose | Zendy; Stefan Masjosthusmann | Zendy; Laura Nimtz | Zendy; Martin Schmuck | Zendy; Saskia Wuttke | Zendy; Julia Tigges | Zendy

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Development of the Concept for Stem Cell-Based Developmental Neurotoxicity Evaluation

Author(s) -

Ellen Fritsche,

Marta Barenys,

Jördis Klose,

Stefan Masjosthusmann,

Laura Nimtz,

Martin Schmuck,

Saskia Wuttke,

Julia Tigges

Publication year - 2018

Publication title -

toxicological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.352

H-Index - 183

eISSN - 1096-6080

pISSN - 1096-0929

DOI - 10.1093/toxsci/kfy175

Subject(s) - neuroscience , progenitor cell , stem cell , human brain , neural stem cell , neurotoxicity , progenitor , brain development , biology , computer science , computational biology , medicine , toxicity , microbiology and biotechnology

Human brain development consists of a series of complex spatiotemporal processes that if disturbed by chemical exposure causes irreversible impairments of the nervous system. To evaluate a chemical disturbance in an alternative assay, the concept evolved that the complex procedure of brain development can be disassembled into several neurodevelopmental endpoints which can be represented by a combination of different alternative assays. In this review article, we provide a scientific rationale for the neurodevelopmental endpoints that are currently chosen to establish assays with human stem/and progenitor cells. Assays covering these major neurodevelopmental endpoints are thought to assemble as building blocks of a DNT testing battery.

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