Editor’s Highlight: Collaborative Cross Mouse Population Enables Refinements to Characterization of the Variability in Toxicokinetics of Trichloroethylene and Provides Genetic Evidence for the Role of PPAR Pathway in Its Oxidative Metabolism | Zendy

Abhishek Venkatratnam | Zendy; Shinji Furuya | Zendy; Oksana Kosyk | Zendy; Avram Gold | Zendy; Wanda M. Bodnar | Zendy; Kranti Konganti | Zendy; David W. Threadgill | Zendy; Kevin Gillespie | Zendy; David L. Aylor | Zendy; Fred A. Wright | Zendy; Weihsueh A. Chiu | Zendy; Ivan Rusyn | Zendy

Open Access

Editor’s Highlight: Collaborative Cross Mouse Population Enables Refinements to Characterization of the Variability in Toxicokinetics of Trichloroethylene and Provides Genetic Evidence for the Role of PPAR Pathway in Its Oxidative Metabolism

Author(s) -

Abhishek Venkatratnam,

Shinji Furuya,

Oksana Kosyk,

Avram Gold,

Wanda M. Bodnar,

Kranti Konganti,

David W. Threadgill,

Kevin Gillespie,

David L. Aylor,

Fred A. Wright,

Weihsueh A. Chiu,

Ivan Rusyn

Publication year - 2017

Publication title -

toxicological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.352

H-Index - 183

eISSN - 1096-6080

pISSN - 1096-0929

DOI - 10.1093/toxsci/kfx065

Subject(s) - population , metabolism , toxicokinetics , trichloroethylene , drug metabolism , metabolite , biology , cytochrome p450 , peroxisome proliferator activated receptor , gene , biochemistry , chemistry , medicine , environmental chemistry , environmental health

Trichloroethylene (TCE) is a known carcinogen in humans and rodents. Previous studies of inter-strain variability in TCE metabolism were conducted in multi-strain panels of classical inbred mice with limited genetic diversity to identify gene-environment interactions associated with chemical exposure.

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