AMP-Activated Protein Kinase Deficiency Rescues Paraquat-Induced Cardiac Contractile Dysfunction Through an Autophagy-Dependent Mechanism | Zendy

Qiurong Wang | Zendy; Lifang Yang | Zendy; Yinan Hua | Zendy; Sreejayan Nair | Zendy; Xihui Xu | Zendy; Jun Ren | Zendy

Open Access

AMP-Activated Protein Kinase Deficiency Rescues Paraquat-Induced Cardiac Contractile Dysfunction Through an Autophagy-Dependent Mechanism

Author(s) -

Qiurong Wang,

Lifang Yang,

Yinan Hua,

Sreejayan Nair,

Xihui Xu,

Jun Ren

Publication year - 2014

Publication title -

toxicological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.352

H-Index - 183

eISSN - 1096-6080

pISSN - 1096-0929

DOI - 10.1093/toxsci/kfu158

Subject(s) - autophagy , mechanism (biology) , paraquat , microbiology and biotechnology , cardiac dysfunction , protein kinase a , chemistry , kinase , ulk1 , biology , medicine , biochemistry , heart failure , apoptosis , ampk , philosophy , epistemology

Paraquat, a quaternary nitrogen herbicide, is a highly toxic prooxidant resulting in multi-organ failure including the heart although the underlying mechanism still remains elusive. This study was designed to examine the role of the cellular fuel sensor AMP-activated protein kinase (AMPK) in paraquat-induced cardiac contractile and mitochondrial injury.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research