Anti-Oxidant N-Acetylcysteine Diminishes Diesel Exhaust-Induced Increased Airway Responsiveness in Person with Airway Hyper-Reactivity | Zendy

Chris Carlsten | Zendy; Meaghan J. MacNutt | Zendy; Zhihong Zhang | Zendy; Francesco Sava | Zendy; Mandy Pui | Zendy

Open Access

Anti-Oxidant N-Acetylcysteine Diminishes Diesel Exhaust-Induced Increased Airway Responsiveness in Person with Airway Hyper-Reactivity

Author(s) -

Chris Carlsten,

Meaghan J. MacNutt,

Zhihong Zhang,

Francesco Sava,

Mandy Pui

Publication year - 2014

Publication title -

toxicological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.352

H-Index - 183

eISSN - 1096-6080

pISSN - 1096-0929

DOI - 10.1093/toxsci/kfu040

Subject(s) - acetylcysteine , airway , crossover study , placebo , medicine , inhalation , anesthesia , diesel exhaust , methacholine , respiratory disease , chemistry , antioxidant , diesel fuel , lung , biochemistry , pathology , alternative medicine , organic chemistry

Inhalation of diesel exhaust (DE) at moderate concentrations causes increased airway responsiveness in asthmatics and increased airway resistance in both healthy and asthmatic subjects, but the effect of baseline airway responsiveness and anti-oxidant supplementation on this dynamic is unknown.

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