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The article highlighted in this issue is Erk Activation is Required for Nrf2 Nuclear Localization during Pyrrolidine Dithiocarbamate Induction of Glutamate Cysteine Ligase Modulatory Gene Expression in HepG2 cells, by Laurie M. Zipper and R. Timothy Mulcahy (pp. 124-134).

Regulation of Nrf2-Mediated Induction of Glutamate Cysteine Ligase Modulatory Gene (GCLM) Expression: Considerations for Future Studies