From Anticholinesterase Toxicity to Alzheimer's Disease: Important Interactions of Cholinergic and NMDA Receptor Systems | Zendy

E.Jon Popke | Zendy

Open Access

From Anticholinesterase Toxicity to Alzheimer's Disease: Important Interactions of Cholinergic and NMDA Receptor Systems

Author(s) -

E.Jon Popke

Publication year - 2003

Publication title -

toxicological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.352

H-Index - 183

eISSN - 1096-6080

pISSN - 1096-0929

DOI - 10.1093/toxsci/kfg050

Subject(s) - nmda receptor , cholinergic , dizocilpine , neuroscience , disease , alzheimer's disease , pharmacology , receptor , toxicity , cholinergic system , medicine , psychology

The article highlighted in this issue is "Dizocilpine Improves Beneficial Effects of Cholinergic Antagonists in Anticholinesterase-Treated Mice," by Andrzej Dekundy, Rafal M. Kaminski, and Waldemar A. Turski (pp. 289-295). It explores the relationship between cholinergic and N-methyl-D-aspartate (NMDA) receptors as mediators of anticholinesterase toxicity. The following review summarizes these findings and discusses their broader implications for central nervous system pharmacology. Alzheimer's disease is discussed as an example of how knowledge of the interactions between NMDA and cholinergic receptors may lead to a better understanding of human disease.

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