Effect of Organochlorine Pesticides on Maturation of Starfish and Mouse Oocytes | Zendy

André Picard | Zendy; Golbahar Pahlavan | Zendy; Stéphanie Robert | Zendy; D. Pesando | Zendy; Brigitte Ciapa | Zendy

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Effect of Organochlorine Pesticides on Maturation of Starfish and Mouse Oocytes

Author(s) -

André Picard,

Golbahar Pahlavan,

Stéphanie Robert,

D. Pesando,

Brigitte Ciapa

Publication year - 2003

Publication title -

toxicological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.352

H-Index - 183

eISSN - 1096-6080

pISSN - 1096-0929

DOI - 10.1093/toxsci/kfg043

Subject(s) - starfish , germinal vesicle , methoxychlor , lindane , pesticide , oocyte , dieldrin , biology , human fertilization , polar body , marine invertebrates , microbiology and biotechnology , chemistry , anatomy , ecology , embryo

Methoxychlor, lindane, and dieldrin are organochlorine pesticides that have been described as altering different reproductive functions in mammals and in invertebrates. However, few data have been published concerning the effects these pesticides have on oocyte maturation and fertilization. The aim of this study was to determine whether these compounds could affect maturation of mouse and starfish oocytes. We observed that germinal vesicle breakdown (GVBD) in starfish oocytes was significantly inhibited by the pesticides. Furthermore, formation of the first meiotic spindle and extrusion of the first polar body were also altered in mouse as well as in starfish. Our results suggest that the three pesticides act on common intracellular targets in invertebrates as well as in vertebrates.

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