Open AccessIsorhamnetin: a flavonoid, attenuated doxorubicin-induced testicular injury via regulation of steroidogenic enzymes and apoptotic signaling gene expression in male rats
Author(s) -
Shama Mustafa,
Muhammad Umar Ijaz,
Qurat Ul Ain,
Tayyaba Afsar,
Ali Almajwal,
Huma Shafique,
Suhail Razak
Publication year - 2022
Publication title -
toxicology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.709
H-Index - 31
eISSN - 2045-4538
pISSN - 2045-452X
DOI - 10.1093/toxres/tfac024
Subject(s) - isorhamnetin , endocrinology , medicine , glutathione peroxidase , glutathione reductase , lactate dehydrogenase , testosterone (patch) , glutathione , biology , lipid peroxidation , sperm , steroidogenic acute regulatory protein , superoxide dismutase , luteinizing hormone , spermatogenesis , oxidative stress , andrology , pharmacology , antioxidant , hormone , flavonoid , biochemistry , gene expression , enzyme , kaempferol , gene
Male reproductive damage is one of the most adverse side effects of doxorubicin (DOX). Isorhamnetin is a natural flavonoid, which displays remarkable antioxidant potential.