Neuromodulatory Effect of Transcranial Direct Current Stimulation on Resting-State EEG Activity in Internet Gaming Disorder: A Randomized, Double-Blind, Sham-Controlled Parallel Group Trial | Zendy

Jiyoon Lee | Zendy; Joon Hwan Jang | Zendy; A Ruem Choi | Zendy; Sun Ju Chung | Zendy; Bomi Kim | Zendy; Minkyung Park | Zendy; Sohee Oh | Zendy; Myung Hun Jung | Zendy; JungSeok Choi | Zendy

Open Access

Neuromodulatory Effect of Transcranial Direct Current Stimulation on Resting-State EEG Activity in Internet Gaming Disorder: A Randomized, Double-Blind, Sham-Controlled Parallel Group Trial

Author(s) -

Jiyoon Lee,

Joon Hwan Jang,

A Ruem Choi,

Sun Ju Chung,

Bomi Kim,

Minkyung Park,

Sohee Oh,

Myung Hun Jung,

JungSeok Choi

Publication year - 2021

Publication title -

cerebral cortex communications

Language(s) - English

Resource type - Journals

ISSN - 2632-7376

DOI - 10.1093/texcom/tgaa095

Subject(s) - transcranial direct current stimulation , resting state fmri , stimulation , electroencephalography , psychology , brain stimulation , prefrontal cortex , randomized controlled trial , medicine , brain activity and meditation , neuroscience , anesthesia , audiology , cognition

Transcranial direct current stimulation (tDCS) has been used as an adjunct therapy for psychiatric disorders; however, little is known about the underlying neurophysiological effects of tDCS in Internet gaming disorder (IGD). We investigated the effects of tDCS on cortical activity using resting-state electroencephalography (EEG) in patients with IGD. This randomized, double-blind, sham-controlled parallel group study of tDCS ( ClinicalTrials.gov NCT03347643) included 31 IGD patients. Participants received 10 sessions (2 sessions per day for 5 consecutive days) of active repetitive tDCS (2 mA for 20 min per session) or sham stimulation. Anode/cathode electrodes were placed over the left and right dorsolateral prefrontal cortex, respectively. In total, 26 participants (active group n = 14; sham group n = 12) completed the trial. Resting-state EEG spectral activity (absolute power) and functional connectivity (coherence) were used to assess the effects of tDCS on cortical activity before stimulation and 1 month after the intervention. Active stimulation of tDCS suppressed increase of intra-hemispheric beta coherence after 1 month, which was observed in the sham group. The 1-month follow-up assessment revealed that absolute gamma power in the left parietal region was decreased in the active group relative to the sham group. Our findings suggest that repetitive tDCS stabilizes fast-wave activity in IGD.

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