Neurometabolic Correlates of Reactive and Proactive Motor Inhibition in Young and Older Adults: Evidence from Multiple Regional 1H-MR Spectroscopy | Zendy

Akila Weerasekera | Zendy; Oron Levin | Zendy; Amanda Clauwaert | Zendy; Kirstin-Friederike Heise | Zendy; Lize Hermans | Zendy; Ronald Peeters | Zendy; Dante Mantini | Zendy; Koen Cuypers | Zendy; Inge Leunissen | Zendy; Uwe Himmelreich | Zendy; Stephan P. Swinnen | Zendy

Open Access

Neurometabolic Correlates of Reactive and Proactive Motor Inhibition in Young and Older Adults: Evidence from Multiple Regional 1H-MR Spectroscopy

Author(s) -

Akila Weerasekera,

Oron Levin,

Amanda Clauwaert,

Kirstin-Friederike Heise,

Lize Hermans,

Ronald Peeters,

Dante Mantini,

Koen Cuypers,

Inge Leunissen,

Uwe Himmelreich,

Stephan P. Swinnen

Publication year - 2020

Publication title -

cerebral cortex communications

Language(s) - English

Resource type - Journals

ISSN - 2632-7376

DOI - 10.1093/texcom/tgaa028

Subject(s) - neurochemical , young adult , psychology , glutamate receptor , striatum , primary motor cortex , neuroscience , motor cortex , inhibitory postsynaptic potential , inferior frontal gyrus , medicine , functional magnetic resonance imaging , developmental psychology , receptor , stimulation , dopamine

Suboptimal inhibitory control is a major factor contributing to motor/cognitive deficits in older age and pathology. Here, we provide novel insights into the neurochemical biomarkers of inhibitory control in healthy young and older adults and highlight putative neurometabolic correlates of deficient inhibitory functions in normal aging. Age-related alterations in levels of glutamate–glutamine complex (Glx), N -acetylaspartate (NAA), choline (Cho), and myo-inositol (mIns) were assessed in the right inferior frontal gyrus (RIFG), pre-supplementary motor area (preSMA), bilateral sensorimotor cortex (SM1), bilateral striatum (STR), and occipital cortex (OCC) with proton magnetic resonance spectroscopy ( 1 H-MRS). Data were collected from 30 young (age range 18–34 years) and 29 older (age range 60–74 years) adults. Associations between age-related changes in the levels of these metabolites and performance measures or reactive/proactive inhibition were examined for each age group. Glx levels in the right striatum and preSMA were associated with more efficient proactive inhibition in young adults but were not predictive for reactive inhibition performance. Higher NAA/mIns ratios in the preSMA and RIFG and lower mIns levels in the OCC were associated with better deployment of proactive and reactive inhibition in older adults. Overall, these findings suggest that altered regional concentrations of NAA and mIns constitute potential biomarkers of suboptimal inhibitory control in aging.

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