Anatomic predictors of response and mechanism of action of upper airway stimulation therapy in patients with obstructive sleep apnea | Zendy

Richard J. Schwab | Zendy; Stephen Wang | Zendy; Johan Verbraecken | Zendy; Olivier M. Vanderveken | Zendy; Paul Van de Heyning | Zendy; Wim Vos | Zendy; Jan W DeBacker | Zendy; Brendan T Keenan | Zendy; Quan Ni | Zendy; Wilfried DeBacker | Zendy

Open Access

Anatomic predictors of response and mechanism of action of upper airway stimulation therapy in patients with obstructive sleep apnea

Author(s) -

Richard J. Schwab,

Stephen Wang,

Johan Verbraecken,

Olivier M. Vanderveken,

Paul Van de Heyning,

Wim Vos,

Jan W DeBacker,

Brendan T Keenan,

Quan Ni,

Wilfried DeBacker

Publication year - 2018

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.1093/sleep/zsy021

Subject(s) - medicine , obstructive sleep apnea , hypoglossal nerve , airway , tongue , stimulation , anesthesia , hyoid bone , soft palate , apnea , anatomy , surgery , pathology

Upper airway stimulation has been shown to be an effective treatment for some patients with obstructive sleep apnea. However, the mechanism by which hypoglossal nerve stimulation increases upper airway caliber is not clear. Therefore, the objective of this study was to identify the mechanism of action of upper airway stimulation. We hypothesized that, with upper airway stimulation, responders would show greater airway opening in the retroglossal (base of the tongue) region, greater hyoid movement toward the mandible, and greater anterior motion in the posterior, inferior region of the tongue compared with nonresponders.

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