Open AccessFast sleep spindle density is associated with rs4680 (Val108/158Met) genotype of catechol-O-methyltransferase (COMT)
Author(s) -
Cláudia Schilling,
Lena Gappa,
Michael Schredl,
Fabian Streit,
Jens Treutlein,
Josef Frank,
Michael Deuschle,
Andreas MeyerLindenberg,
Marcella Rietschel,
Stephanie H. Witt
Publication year - 2018
Publication title -
sleep
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.222
H-Index - 207
eISSN - 1550-9109
pISSN - 0161-8105
DOI - 10.1093/sleep/zsy007
Subject(s) - rs4680 , sleep spindle , catechol o methyl transferase , non rapid eye movement sleep , psychology , neuroscience , genotype , polysomnography , dopaminergic , medicine , endocrinology , biology , dopamine , genetics , electroencephalography , gene
Sleep spindles are a hallmark of NREM stage 2 sleep. Fast sleep spindles correlate with cognitive functioning and are reduced in schizophrenia. Although spindles are highly genetically determined, distinct genetic mechanisms influencing sleep spindle activity have not been identified so far. Spindles are generated within a thalamocortical network. Dopaminergic neurotransmission modulates activity within this network and importantly depends on activity of catechol-O-methyltransferase (COMT). We aimed at testing whether the common functional rs4680 (Val108/158Met) polymorphism of COMT modulates fast spindle activity in healthy participants.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom